Endocrine Abstracts

Introduction: During the perioperative period, surgical operations put patients under a great deal of physical stress. The immune system produces cytokines and other immune mediators in response to this threat. Recent studies have shown that using insulin to regulate blood glucose can reduce systemic inflammation.Objective: The objective of this research was examined how postoperative intensive insulin treatment (IIT) affects the inflammatory response in...

Introduction: Pituitary apoplexy presents as a medical emergency, and usually occurs in people with pituitary macroadenomas. Immediate multidisciplinary expertise and timely intervention is needed to mitigate the associated morbidity. There is controversy regarding the role and the timing of neurosurgical intervention versus conservative management approach to obtain best visual and endocrine outcomes. Here we present a case of a man presenting with pituitary apoplexy and mana...

Langerhan cell histiocytosis (LCH) is a rare; incidence 1.8/100 000. It affects bone, skin, and pituitary but can involve any organ. Diabetes insipidus (DI) is reported in 15–50% of patients, and anterior pituitary dysfunction in 5–20%. We describe a patient whose diagnosis was delayed because of the challenge in making a tissue diagnosis.A 42-year-old female presented in 2010 with sudden onset deafness and vertigo then 1 year later developed D...

Introduction: The use of haematopoietic stem cell transplantation (HSCT) as a curative therapy for life threatening immunodeficiency signalled a paradigm shift in clinical outcomes. However, a subset of patients may experience Thyroid Immune Reconstitution Inflammatory Syndrome (IRIS) following immune reconstitution. This is recognised in the adult population but has received little attention in the paediatric literature. We present, what we believe to be, the first case serie...

A 22 years old woman, with secondary infertility, was found to have secondary hypothyroidism and referred to endocrinology. On review her symptoms consisted of headache for 6 months, amenorrhoea, weight gain and progressive loss of vision in the left eye for 6–9 months, which had been investigated by opticians and opthalmologists. Other history includes Von Willebrand disease type2. Clinical examination confirmed total loss of vision of the left eye and complete temporal ...

Objective: Children with malignant disease are at increased risk of bone disorders, cardiovascular disease and further neoplasia. Vitamin D status may influence this risk and so we assessed Vitamin D levels in children with malignant disease undergoing active treatment or surveillance post-therapy.Study design: This was an outpatient-based cross-sectional study of 60 children with a history of malignancy (cases: median age 11.1 years; range 1.5–24.4...

Aims: To determine whether single parenthood, special needs, ethnicity and indices of multiple deprivation 2007(proxy for social deprivation) influence metabolic control in T1DM.Methodology: Retrospective study (12 months) from 01/01/2007 till 31/12/2007. Data on several demographic and clinical variables were obtained from 105 children with T1DM from a single centre, after applying explicit exclusion criteria. Glycaemic control was assessed using HbA1c ...

Background: Silent corticotroph adenomas (SCAs) are considered to be clinically silent and non-secreting but exhibit positive adrenocorticotropic hormone (ACTH) immunostaining. Whether, SCAs behave more aggressively than other non-functioning adenomas, remains controversial. We characterized our tertiary centre cohort of SCA patients, compared them to gonadotroph adenomas (GAs) and assessed for features predictive of recurrence.Objective: To compare char...

Introduction: Cushing’s disease is usually caused by functional corticotroph microadenomas of the pituitary. Crooke’s cell adenomas are rare, representing approximately 2% of corticotroph adenomas and mostly present as aggressive macroadenomas. Pituitary adenomas showing immunoreactivity for both ACTH and GH are also very uncommon. We present two cases of Cushing’s disease caused by macroadenomas with Crooke’s cell cha...

Introduction: Cushing’s disease is usually caused by functional corticotroph microadenomas of the pituitary. Crooke’s cell adenomas are rare, representing approximately 2% of corticotroph adenomas and mostly present as aggressive macroadenomas. Pituitary adenomas showing immunoreactivity for both ACTH and GH are also very uncommon. We present two cases of Cushing’s disease caused by macroadenomas with Crooke’s cell cha...